io_getcookie man page
io_getcookie — retrieve cookie
void* io_getcookie(int64 fd);
io_getcookie retrieves a cookie (pointer to some anonymous data structure you associated with this descriptor).
Use io_setcookie(3) to associate a cookie with a descriptor.
If you did not associate a cookie with this descriptor, io_getcookie returns NULL.
The idea is that you put the state associated with a TCP connection you serve in a common struct. Then you do not need to have your own data structure to retrieve the state for a connection, you can just use the data structure io_wait already maintains. The lookup works in constant time and should not cause any cache misses.